Background. Mixed lineage leukemia (MLL) gene translocations are found in ~75 % infant and 10 % adult acute leukemia, showing a poor prognosis. Lysine-specific demethylase 1 (LSD1) has recently been implicated to be a drug target for this subtype of leukemia.

The translocation t(9;11)(p22;q23) leading to the leukemogenic fusion gene MLL-AF9 is a frequent translocation in infant acute myeloid leukemia (AML). This study aimed to identify genes and molecular processes downstream of MLL-AF9 (alias MLL-MLLT3) which could assist to develop new targeted therapies for such leukemia with unfavorable prognosis.

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A number of MLL fusion partners such as AF9, ENL, and AF10 are normally components of these multi-protein complexes and thus when fused to MLL may directly recruit DOT1L, resulting in the pathological activation of downstream MLL-fusion target genes. 12,22,23 This explanation suggests that MLL-fusion proteins consisting of a partner gene that ...

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Middle Level Learning is a special publication featuring lessons and activities for middle school teachers. MLL is published online only, 3 times a year. The current issue …

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The dominance of AML-associated leukaemia and the fact that nearly all published studies were performed with MLL-MLLT4, MLL-MLLT3, MLL-MLLT10 and MLL-MLLT1, explains why the available information is biased towards the pathological mechanism of acute myeloid leukaemia.

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Furthermore, JMJD1C was 1 of the top 3 (top 2 are HOXA9 and A10) differentially expressed MLL-AF9 target genes in a data set of human MLL and non-MLL rearranged AML …

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Malignant transformation initiated by Mll-AF9: ... Mll-AF9 was expressed at higher levels in hematopoietic stem ... This study focused on the malignant transformation initiated by the fusion gene Mll-AF9 when expressed at physiologic levels in the knockin model or at supraphysiologic levels in the retroviral model.